ncRNA name | hsa-miR-146b-3p |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Homo sapiens |
Tissues/Cell_line | human monocyte cell line U937; vitreous |
Methods | immunofluorescence, transfection, luciferase reporter assay, qRT-PCR, ELISA |
Expression pattern | down-regulated |
Functional description | In the vitreous of diabetic patients, decreased miR-146b-3p is associated with increased ADA2 activity. Ectopic expression of miR-146b-3p suppressed ADA2 expression, activity, and TNF-α release in the AGA-treated human macrophages. |
PubMed ID | 25815338 |
Year | 2015 |
Title | MicroRNA-146b-3p regulates retinal inflammation by suppressing adenosine deaminase-2 in diabetes. |
Drug-related ncRNA | NO |
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